Cushings disease may be hard to identify

Sometimes a few symptoms are hard to follow to the true source of problems.  This explanation of Cushings disease is very thorough and understandable.  I hope it is helpful but not relevant to your own pet.  I found it at Dr Mercola's website: 

Hi, this is Dr. Karen Becker, and today we’re going to discuss Cushing’s disease. This is the first of a three-part series.

Cushing’s disease was originally diagnosed by Dr. Harvey Cushing in 1932, hence the name. I prefer the correct title of what’s happening to this syndrome: hyperadrenocorticism, which is a bigger much more descriptive word. It means “hyper” or too much, “adreno” referring to the adrenal gland, and “cortisol” or what exactly the syndrome dictates. It’s too much adrenal release of the hormone cortisol.

What Cortisol Does to Your Pet’s Body

Cortisol is your pet’s “fight or flight” hormone. It is designed to be released by your pet’s adrenal glands in very small amounts. When there’s an up-regulation of cortisol demand, your pet can begin producing cortisol in high amounts. This can be toxic to the body.

Cortisol is a very important hormone, it’s part of your pet’s fight-or-flight response, and cortisol is designed to be released in small amounts from the adrenal glands when the body perceives stress. Ultimately speaking, the end result of cortisol release is glucose release from the liver.

Glucose, being sugar, is what provides energy to the muscle cells so that your pet is able to escape a bear, or for a kitten to run up a tree when chased by a dog. It helps your pets ready their bodies either to address confrontation or be able to get away in a life-threatening situation. That’s the big reason why pets release cortisol.

However, cortisol influences a whole host of other biochemical parameters. It influences the body in a whole host of negative ways. Cortisol is also linked to regulation of blood pressure. It can negatively influence electrolyte balance. It is immunosuppressive, so it can negatively impact your pet’s immune system in the long term. It has a negative interaction between bone and fat metabolism.

Needless to say, we’re thankful that cortisol is in our pets’ bodies in small amounts. The goal is to help your pets not over secrete cortisol, which becomes a toxic situation.

Chronic cortisol release translates to chronic signs of stress in your pet. Keep in mind there’s no such thing as good or bad stress for your pet. It’s all stress, so your pet is having the samephysiologic response whether you’re dropping them off at the groomer, they’ve been hit by a truck, they’re all excited that your serving them steak for your birthday dinner, there’s divorce or a new dog in the family, they have a large wound, or they’re dealing with the inflammation of cancer or allergic response. Those are all the same stress.

If you’re thinking, “My pet doesn’t really have stress. I’m moving from place to place, and he travels with me all the time in a brand-new environment,” then that’s still considered a type of stress on your pet’s body.